|
KMID : 1100920190400030151
|
|
Korean Journal of Family Medicine
2019 Volume.40 No. 3 p.151 ~ p.158
|
|
|
Mild Anemia and Risk for All-Cause, Cardiovascular and Cancer Deaths in Apparently Healthy Elderly Koreans
|
|
Han Sil-Vi
Park Min-Seon
Kwon Young-Min
Yoon Hyung-Jin
Chang Yoo-Soo
Kim Ho
Lim Youn-Hee
Kim Su-Gyeong
Ko Ah-Ryoung
|
|
|
Abstract
|
|
|
Background: Being common, mild anemia is sometimes considered a mere consequence of aging; however, aging alone is unlikely to lead to anemia. Therefore, this study aimed to investigate the association between mild anemia and total mortality and cause-specific mortality in apparently healthy elderly subjects.
Methods: A retrospective cohort study was conducted on 10,114 apparently healthy elderly individuals who underwent cancer screening and routine medical check-ups at one Health Promotion Center between May 1995 and December 2007. We defined mild anemia as a hemoglobin concentration between 10.0 g/dL and 11.9 g/dL in women and between 10.0 g/dL and 12.9 g/dL in men. We assessed the relationship between the overall, cardiovascular (CV), and cancer mortality and mild anemia using Cox proportional hazard models.
Results: Mild anemia was present in 143 men (3.1%) and 246 women (6.1%). During an average follow-up of 7.6 years, 495 deaths occurred, including 121 CV and 225 cancer deaths. After adjustments, mild anemia was associated with a 128% increase in the risk of all-cause mortality hazard ratio (HR, 2.28; 95% confidence interval [CI], 1.54? 3.37) in men and cancer-related mortality (HR, 2.25; 95% CI, 1.22?4.13), particularly lung cancer (HR, 2.70; 95% CI, 1.03?7.08) in men, but not in women. In the subgroup analyses based on smoking status, obesity, and age, the associations were more prominent in never or former smoker groups and the older group.
Conclusion: The present study shows that overall and cancer-related mortality was associated with mild anemia in elderly men. Future prospective studies are needed to consolidate our findings.
|
|
|
KEYWORD
|
|
|
Anemia, Mortality, Aged, Cause of Death
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|
|